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<p class="MsoNormal" align="center" style="margin-bottom:0.0001pt;text-align:center;line-height:normal">
<b><span style="font-family:"Times New Roman",serif">Virtual Special Issue on<br>
Data Science for <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">Digital Twin</span></span></span> Technologies </span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:normal">
<b><i><span style="font-family:"Times New Roman",serif">INFORMS Journal on Data Science</span></i></b></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 6pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span lang="EN-CA" style="font-size:10pt;color:windowtext"> </span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 6pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span lang="EN-CA" style="font-size:10pt;color:windowtext">Digital twins—virtual replicas of physical systems that dynamically reflect their real-world counterparts—have emerged as a transformative approach across various </span><span style="font-size:10pt;color:windowtext">domains</span><span lang="EN-CA" style="font-size:10pt;color:windowtext">.
By leveraging advanced data science techniques, digital twins enable predictive analytics, real-time monitoring, and intelligent decision-making, effectively connecting the physical and digital worlds. </span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 6pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span lang="EN-CA" style="font-size:10pt;color:windowtext">At the heart of the <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> concept lies the notion of “twinning,” which underscores the essential requirement
for the virtual counterpart to closely mirror the behavior of the physical system. We believe that data science innovations play a crucial role in making a digital replica a true twin of the corresponding physical system. Motivated by this perspective, this
special issue seeks to explore the intersection of data science <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">and digital twin</span></span></span> technologies, fostering interdisciplinary research that enhances the accuracy, reliability,
and operational value of digital twins. We invite submissions that demonstrate how data science innovations advance the design, implementation, and application of digital twins. Topics of interest include, but are not limited to: </span></p>
<p class="m_-3821263839175168532MsoListParagraph" style="margin:0in 0.9pt 0.0001pt 9pt;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif;text-align:justify">
<b><i><span style="font-size:10pt;font-family:"Times New Roman",serif">1.<span style="font-style:normal;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></i></b><b><i><span style="font-size:10pt;font-family:"Times New Roman",serif">Development
of data-driven and/or hybrid <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> frameworks</span></i></b></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">AI-driven/hybrid
modeling: Efficient replication of complex systems using data-driven, physics-informed, generative, and automated modeling techniques.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Scalable
and intelligent architectures: Design of multi-agent, edge-enabled, human-in-the-loop, and federated systems for distributed <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> environments.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Perception
and state estimation: State identification and simulation readiness through sensor-driven insights.</span></p>
<p class="m_-3821263839175168532MsoListParagraph" style="margin:0in 0.9pt 0.0001pt 9pt;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif;text-align:justify">
<b><i><span style="font-size:10pt;font-family:"Times New Roman",serif">2.<span style="font-style:normal;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></i></b><b><i><span style="font-size:10pt;font-family:"Times New Roman",serif">Data
acquisition, integration, and operation of digital twins</span></i></b></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Cross-domain
data integration: Integration of heterogeneous, high-dimensional, and streaming data using knowledge graphs and semantic techniques for supporting adaptive twin operations.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Secure
and resilient data acquisition process: Development of privacy-preserving, robust and cyber-secure digital infrastructures for reliable data acquisition and processing for <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> operations.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Model
calibration and synchronization: Continuous alignment of digital twins with physical systems via calibration, validation, and dynamic updates. </span></p>
<p class="m_-3821263839175168532MsoListParagraph" style="margin:0in 0.9pt 0.0001pt 9pt;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif;text-align:justify">
<b><i><span style="font-size:10pt;font-family:"Times New Roman",serif">3.<span style="font-style:normal;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></i></b><b><i><span style="font-size:10pt;font-family:"Times New Roman",serif"><span class="gmail-il"><span class="gmail-il"><span class="gmail-il">Digital
twin</span></span></span>-supported decision-making</span></i></b></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt 13.5pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Predictive
and uncertainty-aware forecasting: Simulating future behaviors with uncertainty quantification capability to enable proactive planning, resource optimization, and risk mitigation.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 6pt 12.95pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt;color:windowtext">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span style="font-size:10pt;color:windowtext">Trustworthy
and explainable decision-making: Leveraging synchronized <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> models and interpretable AI to support responsible, human-in-the-loop and automated decisions.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span style="font-size:10pt">We also welcome applications of digital twins in manufacturing, healthcare, energy systems, smart cities, and other domains, grounded in robust methodological and theoretical foundations.</span></p>
<p class="m_-3821263839175168532Default" style="margin:6pt 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<b><span style="font-size:10pt">Submission</span></b></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 6pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span lang="EN-CA" style="font-size:10pt;color:windowtext">To be considered for the virtual special issue on Data Science for <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">Digital Twin</span></span></span> Technologies, submit your manuscript
online via </span><span lang="DE"><a href="https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmc.manuscriptcentral.com%2Fijds&data=05%7C02%7CIEFac.list%40mailman.clemson.edu%7C7fcad4f0505943be053e08ddcb168b30%7C0c9bf8f6ccad4b87818d49026938aa97%7C0%7C0%7C638890019891091313%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=ngjKJLgck5HCj4Z3K7q1D8q7GReHWj4ueLx2hOOdZ%2FM%3D&reserved=0" originalSrc="https://mc.manuscriptcentral.com/ijds" target="_blank"><span lang="EN-CA" style="font-size:10pt;color:windowtext">https://mc.manuscriptcentral.com/ijds</span></a></span><span lang="EN-CA" style="font-size:10pt;color:windowtext">.
Select “Virtual Special Issue on Data Science for <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">Digital Twin</span></span></span> Technologies” as the manuscript type in Step 1. Manuscripts will be assigned to one of the guest editors
for this issue. The virtual special issue aims to provide timely outlets for innovative, cutting-edge research on the aforementioned topics and beyond. A paper submitted to the virtual special issue will be processed right away, and accepted papers will be
published in regular issues without delay. As such, authors are encouraged to submit as soon as they are ready. This virtual special issue will be an online collection of all these articles tied together under a unifying editorial article for greater impact
and outreach.</span></p>
<p class="m_-3821263839175168532Default" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<span lang="EN-CA" style="font-size:10pt;color:windowtext">Given the breadth and diversity of <span class="gmail-il"><span class="gmail-il"><span class="gmail-il">digital twin</span></span></span> research, we are happy to provide a pre-submission assessment
of topic fitness of a potential submission to this special issue. Please feel free to reach out to any of the guest editors by submitting a brief summary (no longer than one page) outlining their intended submission. Please note that pre-submission inquiries
must be made at least one month prior to the submission deadline.</span></p>
<p class="m_-3821263839175168532Default" style="margin:6pt 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<b><span style="font-size:10pt">Important</span></b><b><span style="font-size:10pt;color:windowtext"> Timelines</span></b></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Submission
deadline January 15, 2026. Manuscripts will be reviewed as they are received.</span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">First
round of decision by April 15, 2026.</span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Subsequent
timeline depends on revision time with authors, but guest editors are committed to finish revision review within 60 days.</span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Maximum
two rounds of revisions (three decisions total).</span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span style="font-size:10pt;font-family:Symbol">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">All
final decisions are expected to be made by December</span><span style="font-size:10pt;font-family:"Times New Roman",serif"> 1, 2026.</span></p>
<p class="m_-3821263839175168532Default" style="margin:6pt 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif;color:black;text-align:justify">
<b><span style="font-size:10pt">Guest</span></b><b><span style="font-size:10pt;color:windowtext"> Editors</span></b></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Eunshin
Byon, </span><span lang="DE"><a href="mailto:ebyon@umich.edu" target="_blank"><span style="font-size:10pt;font-family:"Times New Roman",serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">ebyon@umich.edu</span></a></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">,
University of Michigan</span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37)"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Jianhua
Huang, </span><span lang="DE"><a href="mailto:jhuang@cuhk.edu.cn" target="_blank"><span style="font-size:10pt;font-family:"Times New Roman",serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">jhuang@cuhk.edu.cn</span></a></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">,
The Chinese University of Hong Kong, Shenzhen</span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37)"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:black">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Andrea</span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> Matta, </span><span lang="DE"><a href="mailto:andrea.matta@polimi.it" target="_blank"><span style="font-size:10pt;font-family:"Times New Roman",serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">andrea.matta@polimi.it</span></a></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">,
Politecnico Di Milano </span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:black"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0.0001pt;margin-left:9pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10pt;font-family:Symbol;color:rgb(32,34,37)">·<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Eunhye
Song, </span><span lang="DE"><a href="mailto:eunhye.song@isye.gatech.edu" target="_blank"><span style="font-size:10pt;font-family:"Times New Roman",serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">eunhye.song@isye.gatech.edu</span></a></span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">,
Georgia Institute of Technology</span><span lang="DE" style="font-size:10pt;font-family:"Times New Roman",serif;color:rgb(32,34,37)"></span></p>
<p class="MsoNormal"><span lang="DE"> </span></p>
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