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<p class="MsoNormal" align="center" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:normal;layout-grid-mode:char;text-autospace:none">
<b><span style="font-family:"Times New Roman",serif">Virtual Special Issue on <br>
Data Science for Digital Twin Technologies </span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:normal;layout-grid-mode:char;text-autospace:none">
<b><i><span style="font-family:"Times New Roman",serif">INFORMS Journal on Data Science</span></i></b></p>
<p class="Default" style="margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span lang="EN-CA" style="font-size:10.0pt;color:windowtext"> </span></p>
<p class="Default" style="margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span lang="EN-CA" style="font-size:10.0pt;color:windowtext">Digital twins—virtual replicas of physical systems that dynamically reflect their real-world counterparts—have emerged as a transformative approach across various
</span><span style="font-size:10.0pt;color:windowtext">domains</span><span lang="EN-CA" style="font-size:10.0pt;color:windowtext">. By leveraging advanced data science techniques, digital twins enable predictive analytics, real-time monitoring, and intelligent
decision-making, effectively connecting the physical and digital worlds. </span></p>
<p class="Default" style="margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span lang="EN-CA" style="font-size:10.0pt;color:windowtext">At the heart of the digital twin concept lies the notion of “twinning,” which underscores the essential requirement for the virtual counterpart to closely mirror the behavior of the physical system.
We believe that data science innovations play a crucial role in making a digital replica a true twin of the corresponding physical system. Motivated by this perspective, this special issue seeks to explore the intersection of data science and digital twin
technologies, fostering interdisciplinary research that enhances the accuracy, reliability, and operational value of digital twins. We invite submissions that demonstrate how data science innovations advance the design, implementation, and application of digital
twins. Topics of interest include, but are not limited to: </span></p>
<p class="MsoListParagraph" style="margin-right:.9pt;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:normal">
<b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif"><span style="mso-list:Ignore">1.<span style="font:7.0pt "Times New Roman"">
</span></span></span></i></b><b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif">Development of data-driven and/or hybrid digital twin frameworks</span></i></b></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">AI-driven/hybrid modeling: Efficient replication of complex systems using data-driven, physics-informed, generative, and automated modeling techniques.</span></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Scalable and intelligent architectures: Design of multi-agent, edge-enabled, human-in-the-loop, and federated systems for distributed digital twin environments.</span></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Perception and state estimation: State identification and simulation readiness through sensor-driven insights.</span></p>
<p class="MsoListParagraph" style="margin-right:.9pt;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:normal">
<b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif"><span style="mso-list:Ignore">2.<span style="font:7.0pt "Times New Roman"">
</span></span></span></i></b><b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif">Data acquisition, integration, and operation of digital twins</span></i></b></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Cross-domain data integration: Integration of heterogeneous, high-dimensional, and streaming data using knowledge graphs and semantic techniques for supporting adaptive twin operations.</span></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Secure and resilient data acquisition process: Development of privacy-preserving, robust and cyber-secure digital infrastructures for reliable data acquisition and processing for digital twin
operations.</span></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Model calibration and synchronization: Continuous alignment of digital twins with physical systems via calibration, validation, and dynamic updates. </span></p>
<p class="MsoListParagraph" style="margin-right:.9pt;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:normal">
<b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif"><span style="mso-list:Ignore">3.<span style="font:7.0pt "Times New Roman"">
</span></span></span></i></b><b><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif">Digital twin-supported decision-making</span></i></b></p>
<p class="Default" style="margin-right:0in;margin-bottom:0in;margin-left:13.5pt;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Predictive and uncertainty-aware forecasting: Simulating future behaviors with uncertainty quantification capability to enable proactive planning, resource optimization, and risk mitigation.</span></p>
<p class="Default" style="margin-right:0in;margin-bottom:6.0pt;margin-left:12.95pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt;color:windowtext"><span style="mso-list:Ignore">●<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;color:windowtext">Trustworthy and explainable decision-making: Leveraging synchronized digital twin models and interpretable AI to support responsible, human-in-the-loop and automated decisions.</span></p>
<p class="Default" style="text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span style="font-size:10.0pt">We also welcome applications of digital twins in manufacturing, healthcare, energy systems, smart cities, and other domains, grounded in robust methodological and theoretical foundations.</span></p>
<p class="Default" style="margin-top:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<b><span style="font-size:10.0pt">Submission</span></b></p>
<p class="Default" style="margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span lang="EN-CA" style="font-size:10.0pt;color:windowtext">To be considered for the virtual special issue on Data Science for Digital Twin Technologies, submit your manuscript online via
</span><span lang="DE"><a href="https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmc.manuscriptcentral.com%2Fijds&data=05%7C02%7Ciefac.list%40mailman.clemson.edu%7C9ea69397bbff432a14ae08dd7e285e5e%7C0c9bf8f6ccad4b87818d49026938aa97%7C0%7C0%7C638805434047656543%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=UpGPOBJntXSCb%2BTZFVxVDADFLKrAuxLU%2FaOheV6j5U8%3D&reserved=0" originalSrc="https://mc.manuscriptcentral.com/ijds"><span lang="EN-CA" style="font-size:10.0pt;color:windowtext">https://mc.manuscriptcentral.com/ijds</span></a></span><span lang="EN-CA" style="font-size:10.0pt;color:windowtext">. Select
“Virtual Special Issue on Data Science for Digital Twin Technologies” as the manuscript type in Step 1. Manuscripts will be assigned to one of the guest editors for this issue. The virtual special issue aims to provide timely outlets for innovative, cutting-edge
research on the aforementioned topics and beyond. A paper submitted to the virtual special issue will be processed right away, and accepted papers will be published in regular issues without delay. As such, authors are encouraged to submit as soon as they
are ready. This virtual special issue will be an online collection of all these articles tied together under a unifying editorial article for greater impact and outreach.</span></p>
<p class="Default" style="text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<span lang="EN-CA" style="font-size:10.0pt;color:windowtext">Given the breadth and diversity of digital twin research, we are happy to provide a pre-submission assessment of topic fitness of a potential submission to this special issue. Please feel free to
reach out to any of the guest editors by submitting a brief summary (no longer than one page) outlining their intended submission. Please note that pre-submission inquiries must be made at least one month prior to the submission deadline.</span></p>
<p class="Default" style="margin-top:6.0pt;text-align:justify;text-justify:inter-ideograph;layout-grid-mode:char">
<b><span style="font-size:10.0pt">Important</span></b><b><span style="font-size:10.0pt;color:windowtext"> Timelines</span></b></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Submission deadline January 15, 2026. Manuscripts will be reviewed as they are received.</span></p>
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<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">First round of decision by April 15, 2026.</span></p>
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<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Subsequent timeline depends on revision time with authors, but guest editors are committed to finish revision review within 60 days.</span></p>
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<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Maximum two rounds of revisions (three decisions total).</span></p>
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<span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">All final decisions are expected to be made by December</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif">
1, 2026.</span></p>
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<b><span style="font-size:10.0pt">Guest</span></b><b><span style="font-size:10.0pt;color:windowtext"> Editors</span></b></p>
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<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Eunshin Byon,
</span><span lang="DE"><a href="mailto:ebyon@umich.edu"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#1155cc;background:white">ebyon@umich.edu</span></a></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">,
University of Michigan</span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Jianhua Huang,
</span><span lang="DE"><a href="mailto:jhuang@cuhk.edu.cn"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#1155cc;background:white">jhuang@cuhk.edu.cn</span></a></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">,
The Chinese University of Hong Kong, Shenzhen</span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:black"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Andrea</span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:black;background:white"> Matta,
</span><span lang="DE"><a href="mailto:andrea.matta@polimi.it"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#1155cc;background:white">andrea.matta@polimi.it</span></a></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:black;background:white">,
Politecnico Di Milano </span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:black"></span></p>
<p class="MsoNormal" style="margin-right:0in;margin-bottom:0in;margin-left:9.0pt;margin-bottom:.0001pt;line-height:normal;vertical-align:baseline">
<span lang="DE" style="font-size:10.0pt;font-family:Symbol;color:#202225"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">Eunhye Song,
</span><span lang="DE"><a href="mailto:eunhye.song@isye.gatech.edu"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#1155cc;background:white">eunhye.song@isye.gatech.edu</span></a></span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225;background:white">,
Georgia Institute of Technology</span><span lang="DE" style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#202225"></span></p>
<p class="MsoNormal"><span lang="DE"> </span></p>
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